Role of Retinol-binding Protein 4 as an Early Biomarker for Diabetic Nephropathy in Type 2 Diabetic Patients

Authors

  • Hayder Huwais Jarullah
  • Inaam Ahmed Ameen

DOI:

https://doi.org/10.37506/mlu.v21i2.2744

Keywords:

Albuminuria, renal impairment, RBP4, microalbuminuria, macroalbuminuria, diabetic nephropathy

Abstract

Assess the relationship and diagnostic performance of retinol-binding protein 4 (RBP-4) as a biomarker of
diabetic nephropathy (DN) at different levels of albuminuria (normo-, micro- and macro-albuminuria). A
case-control study, that involved 185 participants, 47 were healthy control, and 138 diabetic patients (46
were normoalbuminuric patients [NA], 48 patients were microalbuminuria [MiA], and 44 patients were
macroalbuminuria [MaA]). All diabetic patients were treated with antidiabetic medication (metformin and/
or oral sulfonylureas), all the participants were interviewed by the researcher, and full medical (history of
liver, kidney, lung, and other diseases), and sociodemographic data taken from them and recorded in the
questionnaire. In the present study, RBP-4 was 14.08±1.82 ng/ml in the control group, 15.98±3.74 ng/ml
in the normoalbuminuria (NA) group, 30.38±6.02 ng/ml in the micro-albuminuria (MiA), and 41.01±5.78
ng/ml for macro-albuminuria (MaA), there was a significant difference between all their groups compared
to control (p-value <0.001), and between each other (p-value <0.001) except that no significant difference
found between control and normoalbuminuria. In conclusion, RBP4 is an excellent predictor of both
microalbuminuria and microalbuminuria, there was an inverse relationship between RBP4 with GFR, which
indicate it is a good predictor for the progression of diabetic kidney impairment.

Author Biographies

Hayder Huwais Jarullah

Lecturer, College of Pharmacy, Baghdad University, Baghdad, Iraq

Inaam Ahmed Ameen

Ass Proof, College of Pharmacy, Baghdad University, Baghdad, Iraq

Published

2021-03-12

How to Cite

Hayder Huwais Jarullah, & Inaam Ahmed Ameen. (2021). Role of Retinol-binding Protein 4 as an Early Biomarker for Diabetic Nephropathy in Type 2 Diabetic Patients. Medico Legal Update, 21(2), 578-583. https://doi.org/10.37506/mlu.v21i2.2744