Evaluation of a New Green Zirconium Nanoparticle from Lemon and Peel Extract Antioxidant and Anticancer Activity
Keywords:Green zirconium NPs, lemon, peel extract, antioxidant, anticancer
Objective: This study was planned to synthesizea novel green Zirconium nanoparticles (ZrNPs), from
lemon/and lemon peel with zirconium salt and test its bioactivity against free radicals, and certain cancer cell
lines (MCF-7).Materials and Method: Lemon/peel extracts were prepared, mixedwith water and heated to
80 °C, and filtered. The zirconium nanoparticles were synthesized using (ZrCl3) solution which was added
to the filtrate (juice and peel) in 1:1 proportion, and UV-Visible was taken. Different concentrations were
prepared to study their activity. DPPH assay against free radicals and cytotoxicity against MCF-7 cell line
were measured. Results: UV-Visible absorbance of lemon peel/and lemon NPs was carried out and it was
found that NPs gave peaks at 457 and 478 nm, while lemon NPs gave peak at 217, and 270 nm. antioxidant
activity of all the solutions were carried out, it was found that the peel and juice nanoparticles gave the
highest scavenging activity % in all concentrations at 800, 600, 400, and 200 µg/ml which were 93, 78, 57,
and 20% respectively. The activity against MCF-7 cancer cell line, the highest inhibition percentage effect
(95.16) showed by NPs + Peel, while the lowest effect was 18.42.
Conclusion: Novel NPs were synthesized form ZrCl3 and lemon extract/and lemon peel, it was found that
the last one is more active against free radical and MCF-7 cell line.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.