Evaluation of a New Green Zirconium Nanoparticle from Lemon and Peel Extract Antioxidant and Anticancer Activity

Authors

  • Rajaa H. Salih
  • Sundus Hameed Ahmed
  • Rasha Sattam Hameed
  • Isam Hussain T. Al-Karkhi

DOI:

https://doi.org/10.37506/mlu.v21i2.2810

Keywords:

Green zirconium NPs, lemon, peel extract, antioxidant, anticancer

Abstract

Objective: This study was planned to synthesizea novel green Zirconium nanoparticles (ZrNPs), from
lemon/and lemon peel with zirconium salt and test its bioactivity against free radicals, and certain cancer cell
lines (MCF-7).Materials and Method: Lemon/peel extracts were prepared, mixedwith water and heated to
80 °C, and filtered. The zirconium nanoparticles were synthesized using (ZrCl3) solution which was added
to the filtrate (juice and peel) in 1:1 proportion, and UV-Visible was taken. Different concentrations were
prepared to study their activity. DPPH assay against free radicals and cytotoxicity against MCF-7 cell line
were measured. Results: UV-Visible absorbance of lemon peel/and lemon NPs was carried out and it was
found that NPs gave peaks at 457 and 478 nm, while lemon NPs gave peak at 217, and 270 nm. antioxidant
activity of all the solutions were carried out, it was found that the peel and juice nanoparticles gave the
highest scavenging activity % in all concentrations at 800, 600, 400, and 200 µg/ml which were 93, 78, 57,
and 20% respectively. The activity against MCF-7 cancer cell line, the highest inhibition percentage effect
(95.16) showed by NPs + Peel, while the lowest effect was 18.42.
Conclusion: Novel NPs were synthesized form ZrCl3 and lemon extract/and lemon peel, it was found that
the last one is more active against free radical and MCF-7 cell line.

Author Biographies

Rajaa H. Salih

Lecturer

Sundus Hameed Ahmed

Ass. Prof

Rasha Sattam Hameed

Ass. Lecturer, College of Science, Al- Mustansiriyah University, Baghdad, Iraq

Isam Hussain T. Al-Karkhi

Ass. Prof., Former Ass. Prof., University of Baghdad

Published

2021-03-12

How to Cite

Rajaa H. Salih, Sundus Hameed Ahmed, Rasha Sattam Hameed, & Isam Hussain T. Al-Karkhi. (2021). Evaluation of a New Green Zirconium Nanoparticle from Lemon and Peel Extract Antioxidant and Anticancer Activity. Medico Legal Update, 21(2), 977-981. https://doi.org/10.37506/mlu.v21i2.2810

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