QTc Interval Prolongation in Drug Resistant-Tuberculosis Patients Treated with Shorter Treatment Regimen

Authors

  • Tutik Kusmiati
  • Yulia Devina Suci
  • Soedarsono

DOI:

https://doi.org/10.37506/mlu.v21i2.2855

Keywords:

Prolonged QTc, Drug Resistant-Tuberculosis, Shorter Treatment Regimen

Abstract

Background: Shorter Treatment Regimen (STR) is a combination of treatments with a shortened period
from 20-24 months to 9-11 months. Shortened treatment requires a higher dose of drug to kill resistant
bacteria. Corrected QT (QTc) interval prolongation is one of the severe side effects of treatment.
Objective: This study aimed to find the factors of QTc prolongation in Drug Resistant-Tuberculosis (DRTB) patients treated with STR during an intensive phase.
Method: An analytical retrospective study was conducted at Dr. Soetomo General Academic Hospital,
Surabaya, Indonesia. DR-TB patients on the STR regimen were collected based on medical records between
September 2017 to August 2018. QTc interval was calculated by Fredericia formula. The relationship
between QTc interval at baseline and occurrence of QTc prolongation was analyzed using Chi-Square of
fisher’s exact test.
Results: Among 108 patients on the STR regimen, there were 20 (28%) patients experienced moderate
QTc prolongation (471-500 ms), and 31 (28%) patients had severe QTc prolongation (>500 ms) during four
months observation period in STR treatment. The prolonged QTc interval was significantly related to QTc
interval at baseline (p = 0.001). The QTc interval at baseline correlated significantly with the start time of
QTc prolongation (p < 0.001). Risk factors of age, gender, comorbid, hypertension, and potassium level at
baseline had a significant negative correlation to QTc prolongation.
Conclusion: The prolonged QTc interval was significantly related to QTc interval at baseline. The QTc
interval at baseline correlates significantly with the start time of QTc prolongation.

Author Biographies

Tutik Kusmiati

Medical Staff, Infection Division, Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine,
Universitas Airlangga-Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Yulia Devina Suci

Resident, Departement
of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga-Dr. Soetomo General
Academic Hospital, Surabaya, Indonesia

Soedarsono

Assistance Professor, Infection Division, Departement of Pulmonology
and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga-Dr. Soetomo General Academic Hospital,
Surabaya, Indonesia

Published

2021-03-12

How to Cite

Tutik Kusmiati, Yulia Devina Suci, & Soedarsono. (2021). QTc Interval Prolongation in Drug Resistant-Tuberculosis Patients Treated with Shorter Treatment Regimen. Medico Legal Update, 21(2), 1208-1215. https://doi.org/10.37506/mlu.v21i2.2855