Screening of Thyroid Function Test During First Trimester of Pregnancy
Keywords:Thyroid Peroxidase Antibody, Thyroid Stimulating hormone, Tri iodothyronine, Tetra iodothyronine.
Introduction: During pregnancy maternal thyroid dysfunction has been associated with a number of adverse
outcomes, like preterm birth, placental abruption, fetal death and impaired neurological development in
the child. The presence of Thyroid Peroxidase Antibody (TPO-Ab) results miscarriage, preterm birth and
maternal post-partum thyroid disease. Hypothyroidism is closely associated with the presence of Thyroid
Peroxidase Antibody. If a pregnant woman is positive for TPO-Ab in early pregnancy, her chances to
developing thyroid abnormalities.
Objective: To find out the level of TPO-Ab and thyroid status in first trimester of pregnancy. Method:
Observational cross-sectional Study was designed in Department of Biochemistry, Medical college,
Vadodara, Gujarat, India.
Sample Size: 200 Normal pregnant women that randomly selected from the first trimesters of pregnancy.
The study parameters were - thyroid peroxidase anti-body (TPO-Ab); serum thyroid stimulating hormone
(TSH); serum T3 and serum T4.
Result: Our study found that 30(15%) pregnant women of first trimester was hypothyroidism (TSH
>2.5mIU/l) Out of these 30 females, 9(4.5%) had overt hypothyroidism & 21 (10.5%) had subclinical
hypothyroidism, among these 30 subjects, 26(13%) had found TPO-Ab positive (TPO-Ab >35 IU//mL)
there was a significant positive correlation between positive TPO-Ab and serum TSH level of study subjects
and there was a negative correlation between serum TSH and serum T4,T3 level in study subjects.
Conclusion: In this study we found 15% prevalence of hypothyroidism (4.5 % overt & 10.5 % subclinical)
in first trimester of pregnancy. We found positive TPO-Ab in 13% of pregnant females and all these had
some thyroid dysfunctions, subclinical or overt hypothyroidism, subclinical being much more common than
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