Histopathology Study of the Platelet Rich Plasma on the Wound Healing in Rabbits
Keywords:Platelet Rich Plasma, Wound Healing, Rabbits
The study aimed to evaluate the beneficial effect of platelets rich plasma (PRP) on wound heal in rabbit.
Eighteen healthy male adult rabbit were used they were randomly divided into two equal groups (control
group 9, treated group 9). Under aseptic technique 3 cm skin incision was made in the back (dorsal) of
animal by scalpel, after that the incision was sutured immediately by silk suture materials 0.2 USP used
simple interrupted technique treated group receive immediately post operation PRP (1ml) was injected at
the site of the wound, while control group left without treatment. Skin healing process follow up 1,2 and
3 weeks post operation by histopathological examination, the result display in treated group on the first
week post operation development of granulation tissue with epithelial regeneration. 2 weeks post operation
show intense inflammatory infiltration with desquamation tissue, granulation tissue and new blood vessels
formation. 3 weeks post operation showed proliferation of fibroblast with deposition of collagen, while in
control group histopathological examination in the first week show intense inflammatory infiltrate with
desquamated tissue and hemorrhage, 2 weeks post operation show area of intensive acute inflammatory
infiltrate, 3 weeks post operation show area of chronic inflammatory infiltrate with tissue debris and giant
cells, the healing of treated group better than control group.
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