Association of Serum Vitamin D Levels on Response Therapy in Patient Lung Adenocarcinoma Advanced with Targeted Therapy
Keywords:Lung adenocarcinoma, vitamin D, response therapy, tyrosine kinase inhibitors
Objective: This study aimed to analysis the associated of serum vitamin D levels and response therapy
in advanced lung adenocarcinoma patient after used TKIs. Methods: This study was an observational
analytic study. The subjects where patient with advanced lung adenocarcinoma who received tyrosine kinase
inhibitors (TKIs) for 3 months at Dr. Soetomo general hospital Surabaya from July to March 2021 who met
the inclusion and exclusion criterias. The independent variable in this study are the serum levels of vitamin
D and response therapy objective (RECIST criteria) as the dependent variable. Results: The results of
stastitical analysis showed that there was no significant associated of serum vitamin D levels and response
therapy (p>0.05). Patient insufficiency with partial response had a greater number than patient sufficiency
with partial response. The mean of vitamin D levels in patient with progressive disease was the highest.
Conclusion: Although the serum levels of vitamin D in lung cancer was lower but in this study showed that
there was no significant associated of serum vitamin D levels and response therapy in patient advanced lung
adenocarcinoma with tyrosine kinase inhibitors.
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