Estimation the Level of Follicular Fluid Follistatin in Women Undergoing Intracytoplasmic Sperm Injection

Authors

  • Baydaa Lateef Hameed 1, Mutaz Sabah Ahmeid 2, NihadKhalawe Tektook3 , Hashim Abdulsattar Jabar 4

DOI:

https://doi.org/10.37506/mlu.v20i1.564

Keywords:

Follistatin; Follicular Fluid; ICSI; Infertility; Pregnancy

Abstract

Objectives: A prospective study carried out in Kirkuk city from 15th of January 2019 to 10th of April 2019 , included 45 women who were enrolled in assisted reproductive technology (ART) programs in infertility Centre /Kirkuk, Iraq. Patients and method: All women were subjected to the basic fertility work-up at the infertility center which consists of history taking,physical examination, ovulation detection, evaluation of tubal patency and uterine cavity . The average age of the included women ranged between 20 and 42 years old. All women were enrolled in short protocol type of IVF/ICSI cycle and they had normal menstrual cycles. Nearly 5 ml of follicular fluid was obtained from all women undergoing ICSI for estimation of follistatin level by ELISA technique. Results : The present study showed that 31.1% (14 of 45) of women underwent ISCI technique became pregnant and 68.9% were non-pregnant (31of 45). The highest mean of age were recorded among pregnant women compared with non-pregnant women (32.21± 6.68 v.s31.80±5.38 year) although the result was non-significant (P: > 0.05). The highest mean of BMI were recorded among non-pregnant women compared with pregnant women (23.92 ± 1.55 v.s 25.36±1.99 kg/m2), the result was significant. The highest mean level of follicular fluid follistatin evaluated in pregnant compared with non pregnant (10.20±0.30 v.s 9.83±0.58 ng/ml) although the result was high significant difference (p: < 0.05). The study showed that there was negative correlation of follicular fluid follistatin level with age in pregnant women (r= -0.3), with positive correlation of with age in non-pregnant women. Conclusions: There was a highly significant relation of follicular fluid follistatin with pregnancy outcomes after ICSI.

Author Biography

  • Baydaa Lateef Hameed 1, Mutaz Sabah Ahmeid 2, NihadKhalawe Tektook3 , Hashim Abdulsattar Jabar 4

    1 Kirkuk health directorate, Kirkuk city, Iraq, 2 M.B.Ch.B, M.Sc, Ph.D in clinical Biochemistry, College of Medicine, Tikrit University , 3 Ph.D in immunology ,Middle Technical University- College of Medical & Health Technology-Baghdad- Iraq; 4B.Sc, M.Sc in Chemistry, Department of Biochemistry, College of Medicine, Tikrit University , Iraq

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Published

2020-04-09

How to Cite

Estimation the Level of Follicular Fluid Follistatin in Women Undergoing Intracytoplasmic Sperm Injection. (2020). Medico Legal Update, 20(1), 1360-1365. https://doi.org/10.37506/mlu.v20i1.564

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