Study of Inflammatory Biomarker (PARC/CCL 18) in Chronic Obstructive Pulmonary Disease and its Correlation with Disease Severity in South Indian Population

Authors

  • Ganesan. R, Varadharaju, Vishnukanth, Karthik, Gaur. G.S

DOI:

https://doi.org/10.37506/ijop.v7i3.169

Keywords:

Chronic obstructive pulmonary disease, Pulmonary and activation regulated chemokine ligand-18, lung.

Abstract

Aim

Our recent studies have shown that inflammatory biomarker (PARC/CCL 18) in chronic pulmonary disease and its correlation with disease severity in south Indian population. Chronic obstructive pulmonary disease (COPD) is a lung disease characterised by chronic obstruction of lung airways which is not entirely reversible. Pulmonary and activation-regulated chemokine ligand-18(PARC/CCL18) is a 7-kD protein that is constitutively expressed by monocytes/macrophages and dendritic cells and is secreted predominantly in the lung. It is a promising inflammatory marker in COPD.

Material and Method

This was a Descriptive study conducted in 130 male COPD patients. It was designed to assess the specific inflammatory marker and study their relationship with disease severity levels in male COPD patients.

Results

inflammatory biomarkers of Pulmonary and activation regulated chemokine ligand-18 levels were significantly (P<0.003) increased in very severe COPD patients when compared with mild, moderate and severe COPD patients.

Conclusion

From the present study, we conclude that in COPD specific biomarker serum PARC/CCL18 associated with disease severity

Author Biography

  • Ganesan. R, Varadharaju, Vishnukanth, Karthik, Gaur. G.S

    Ganesan R1, Varadharaju2,*, Vishnukanth3, Karthik3, Gaur G.S.4

    1Assistant Professor, Department of Physiology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil nadu, India

    2Assistant Professor, Department of Physiology, JIPMER, Pondicherry, India

    3Associate Professor, Department of Physiology, JIPMER, Pondicherry, India

    4Professor & Head, Department of Physiology, JIPMER, Pondicherry, India

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Published

2019-07-25

Issue

Vol. 7 No. 3 (2019): International Journal of Physiology

Section

Articles

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How to Cite

Study of Inflammatory Biomarker (PARC/CCL 18) in Chronic Obstructive Pulmonary Disease and its Correlation with Disease Severity in South Indian Population. (2019). International Journal of Physiology, 7(3), 231-234. https://doi.org/10.37506/ijop.v7i3.169