Genetican Alysis of the Role of Connexin 37 Polymorphism in Spontaneous Abortion
Keywords:Connexin 37 gene, Gap junctions, Spontaneous abortion, Protective factor, Smoking, Cardiovascular disease, Candidate gene. aCVD: Cardiovascular disease of atherosclerotic origin, CI: Confidence interval, Cx37: Connexin 37, DNA: Deoxyribonucleic acid, OR: Odds ratio, SA: Spontaneous abortion, VEGF: Vascular endothelial growth factor
Introduction: Among unique cardiovascular risk factors in women are complications during pregnancy,
including miscarriage. Important risk factor is also genetic background. One of powerful candidate genes
for cardiovascular disease of atherosclerotic origin (aCVD) is gene for connexin 37 (Cx37) with strong
gene-environment interaction including smoking status, that is also strong risk factor for complications in
pregnancy including spontaneous abortion (SA). Material and Methods: We analysed association between
SA and Cx37 gene polymorphism (1019C>T; Pro319Ser) in 547 foetuses and its potential interaction with
smoking status of mothers. Using genetic analyses from women from general population as controls, ORs
for T allele, found in our previous studies to be protective against a CVD, were calculated. This study was
a secondary analysis of a randomized controlled trial. Results and Conclusion: T allele carriers (foetuses),
had OR 0.91 (95 % CI 0.72-1.14) and no interaction with smoking was observed. In conclusion, no significant
association between Cx37 polymorphism and SA was observed and no modifying effect of smoking status
on this association was detected.
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