Impact of Diabetes Type 2 in Adults on Autonomic Modulation at Rest and in Response to the Active Orthostatic Test

Authors

  • Vinodh R S
  • Veerendra Kamath
  • Shabina C
  • Shankarappa C

DOI:

https://doi.org/10.37506/ijop.v10i1.3212

Keywords:

Heart Rate Variability, Autonomic Dysfunction, Type 2 Diabetic Mellitus

Abstract

Background: Cardiovascular autonomic neuropathy Is one of the most common complications of
Diabetes Mellitus Type 2(DM2). Heart rate variability (HRV} Is a noninvasive measure of cardiac
autonomicmodulation. Reduced HRVIs an Independent cardiovascula rrisk factor and has been
proposed as amarker of increased risk of mortality.Very few studies have measured Changesin
HRV in DM2 in India.
Objectives: To analyze the autonomic modulation responses In DM2 patients by means of HRV
indices.
Methodology: Across-sectional study of 20 Type 2 Diabetic mellitus from age groups 30-
S0 years and age and gender matchenon-diabetic subjects as controls. Subjects satisfying in
clusion and exclusion criteria and gave written informed consent were randomly invited to take
partin the study. Initial assessment was done for HTN, hyperlipidemia, smoking, cardiovascular
disease, family
H/o DM2, FBS >130 mg/di, Body mass index (BMI) >25 kg/m,DM2, duration of disease, and
Heart rate.
Bloodpressure: measure dmercury sphygmomanometer aftera5-minrest. Electrocardiogram
wasrecordedusingPower Lab• (ADlnstruments). The time domain, frequencydomainvariables,
and nonli near parameters was meas ured from ECGusing Lab Chart• software.
Results and Conclusion : Time domain Variablesnamely AverageRR, SDRR,SDARR,rMSSD
andPNNS0(%) and Frequency domain Variables; High frequency (HF) power, Low frequency
(LF) power and Very Lowfrequency (LF)power Non-Linear Variables; S01and SD2 were
reuced in patients with diabetes Mellitus compared to normal control but was not statistically
significant. One of the reasons couldbesmallsamplesize. Study should be repeated in large
sample size.

Author Biographies

  • Vinodh R S

    Associate Professor, Dept. of Physiology,Vydehi Institute of Medical Sciences and Research Center, #82, EPIPArea, Nallurahalli, Whitefield, Bangalore

  • Veerendra Kamath

    Junior Research Scholar, Dept. of Physiology,Vydehi Institute of Medical Sciences and Research Center, #82, EPIPArea, Nallurahalli, Whitefield, Bangalore

  • Shabina C

    AssistantProfessor, Dept. of Physiology,Vydehi Institute of Medical Sciences and Research Center, #82, EPIPArea, Nallurahalli, Whitefield, Bangalore

  • Shankarappa C

    Prof & HOD, Dept. of Physiology,Vydehi Institute of Medical Sciences and Research Center, #82, EPIPArea, Nallurahalli, Whitefield, Bangalore

Downloads

Published

2022-01-04

Issue

Vol. 10 No. 1 (2022): International Journal of Physiology

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright Ownership: Authors retain copyright ownership of their work after publication in IJOP. However, they grant the journal an exclusive Creative Commons license.

Creative Commons License: The authors grant IJOP the right to exclusively apply a Creative Commons license to their work upon publication. This license permits use, distribution, and reproduction of the work in any medium, provided that the original work and its source are properly cited. The specific license applied is Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which allows for attribution, non-commercial use, and derivative works.

Editorial Research: Authors grant the journal the right to analyze information obtained from submitted manuscripts for editorial research purposes. This analysis aims to improve the peer-review process, teaching, and training activities.

Warranties: Authors warrant that their work is original, contains no libelous statements, is lawful, and does not infringe upon any copyright, trademark, patent, or proprietary rights of others. Authors agree to indemnify the editors against any costs, expenses, and damages arising from any breach of this warranty.

Views and Opinions: The views and opinions expressed in the article are those of the authors and not necessarily those of the journal.

How to Cite

Impact of Diabetes Type 2 in Adults on Autonomic Modulation at Rest and in Response to the Active Orthostatic Test. (2022). International Journal of Physiology, 10(1), 29-34. https://doi.org/10.37506/ijop.v10i1.3212