Impact of Diabetes Type 2 in Adults on Autonomic Modulation at Rest and in Response to the Active Orthostatic Test
Keywords:Heart Rate Variability, Autonomic Dysfunction, Type 2 Diabetic Mellitus
Background: Cardiovascular autonomic neuropathy Is one of the most common complications of
Diabetes Mellitus Type 2(DM2). Heart rate variability (HRV} Is a noninvasive measure of cardiac
autonomicmodulation. Reduced HRVIs an Independent cardiovascula rrisk factor and has been
proposed as amarker of increased risk of mortality.Very few studies have measured Changesin
HRV in DM2 in India.
Objectives: To analyze the autonomic modulation responses In DM2 patients by means of HRV
Methodology: Across-sectional study of 20 Type 2 Diabetic mellitus from age groups 30-
S0 years and age and gender matchenon-diabetic subjects as controls. Subjects satisfying in
clusion and exclusion criteria and gave written informed consent were randomly invited to take
partin the study. Initial assessment was done for HTN, hyperlipidemia, smoking, cardiovascular
H/o DM2, FBS >130 mg/di, Body mass index (BMI) >25 kg/m,DM2, duration of disease, and
Bloodpressure: measure dmercury sphygmomanometer aftera5-minrest. Electrocardiogram
wasrecordedusingPower Lab• (ADlnstruments). The time domain, frequencydomainvariables,
and nonli near parameters was meas ured from ECGusing Lab Chart• software.
Results and Conclusion : Time domain Variablesnamely AverageRR, SDRR,SDARR,rMSSD
andPNNS0(%) and Frequency domain Variables; High frequency (HF) power, Low frequency
(LF) power and Very Lowfrequency (LF)power Non-Linear Variables; S01and SD2 were
reuced in patients with diabetes Mellitus compared to normal control but was not statistically
significant. One of the reasons couldbesmallsamplesize. Study should be repeated in large
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