Serum Adiponectin Variation And Its Relationships With Certain Markers Of Cardiovascular And Metabolic Risk In Type 2 Diabetes

Authors

  • Maïmouna Touré Laboratoire de Physiologie Humaine et d’Explorations Fonctionnelles, FMPOS, UCAD, Dakar, Sénégal.
  • Diouf NN Laboratoire de Biochimie et de Biologie Moléculaire, UFR Santé, UASZ, Ziguinchor, Sénégal.
  • Pouye PS Laboratoire de Physiologie Humaine et d’Explorations Fonctionnelles, FMPOS, UCAD, Dakar, Sénégal.
  • Ba A Laboratoire de Physiologie Humaine et d’Explorations Fonctionnelles, FMPOS, UCAD, Dakar, Sénégal
  • Kane MO Laboratoire de Physiologie Humaine et d’Explorations Fonctionnelles, FMPOS, UCAD, Dakar, Sénégal.
  • Gueye L Laboratoire de Physiologie Humaine et d’Explorations Fonctionnelles, FMPOS, UCAD, Dakar, Sénégal.
  • Khan NA Physiologie de la Nutrition & Toxicologie, INSERM U1231, UBFC, Dijon, France
  • Samb A Laboratoire de Physiologie Humaine et d’Explorations Fonctionnelles, FMPOS, UCAD, Dakar, Sénégal.

DOI:

https://doi.org/10.37506/t3n00t92

Keywords:

adiponectin, obesity, type 2 diabetes, vascular dysfunction.

Abstract

Introduction : adiponectin seems to participate in the pathophysiology of comorbidities associated with obesity such as type 2 diabetes. Thus, we propose to determine the correlation of serum adiponectin to clinico-biological parameters in type 2 diabetes.

Methodology : this is a case-control study with a bio-anthropometric and a biochemical examination in all participants. The arterial stiffness and the endothelial dysfunction were evaluated. Serum adiponectin and nitric oxide levels were measured by the ELISA sandwich test.

Results : serum adiponectin was significantly lower in type 2 diabetic subjects (p<0.0001). In the control group, serum adiponectin was correlated positively with HDL cholesterol (r=0.279 p=0.005) and negatively with body mass index (r=-0.339 p=0.001), waist-hip ratio (r=-0.290 p=0.004), visceral fat level (r=-0.246 p=0.014), glycated hemoglobin (r=-0.215 p=0.004), insulin resistance index (r=-0.391 p<0.0001), apolipoprotein B–apolipoprotein A ratio (r=-0.226 p=0.024) and total cholesterol/HDL cholesterol (r=-0.199 p=0.047). In the diabetic group, serum adiponectin was correlated positively with HDL cholesterol (r=0.331 p=0.001) and fingers-toes pulse wave velocity (r=0.228 p=0.024), and negatively with heart rate (r=-0.224 p=0.027), reactive hyperhemic index (r=-0.364 p=0.126), total cholesterol (r=-0.212 p=0.034), and triglycerides/HDL cholesterol (r=-0.223 p=0.026).

Conclusion : serum adiponectin decreases with obesity. It would protect against insulin resistance and cardiovascular dysfunction during type 2 diabetes.

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Published

2024-09-13

Issue

Vol. 12 No. 2 (2024): International Journal of Physiology

Section

Original Article

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How to Cite

Serum Adiponectin Variation And Its Relationships With Certain Markers Of Cardiovascular And Metabolic Risk In Type 2 Diabetes . (2024). International Journal of Physiology, 12(2), 10-16. https://doi.org/10.37506/t3n00t92

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