Effect of Ventromedial Hypothalamus on Food Intake, Body Weight, Insulin Resistance, Lipid Profile and Thyroid Profile in High-Fat Diet Obese Female Wistar Rats
Keywords:High-fat diet, ventromedial hypothalamus, obese rat.
Diet is one of the risk factors for obesity and VMH plays a substantial role in food intake and obesity. Food intake and body weight differ preferentially with gender. Insulin resistance, thyroid, and lipid profile are intimately linked to body metabolism. Thus, this study was conducted to assess the role of VMH on metabolism
Materials and Method
The study was conducted in the Dept. of Physiology, JIPMER after ethics committee approval. The animals were fed on HFD (total of 12 female albino Wistar rats) for a period of 10 weeks. After obtaining a basal recording of food intake, body weight, glucose, insulin, thyroid, and lipid profile for a period of 1 week, animals were divided into control and experimental subgroups (each 6 female). Experimental rats underwent electrolytic ablation of VMH whereas control rats underwent sham lesion. Then a post-lesion recording was taken for four weeks and compared between groups with appropriate statistics.
VMH lesion increased food intake, body weight, blood glucose, insulin, and insulin resistance in the experimental group. VMH lesion didn't have much influence on lipid profile and thyroid profile.
VMH has a significant role in feeding behavior, adiposity genesis, insulin-glucose homeostasis, and lipid metabolism
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