Effect of Ventromedial Hypothalamus on Food Intake, Body Weight, Insulin Resistance, Lipid Profile and Thyroid Profile in High-Fat Diet Obese Female Wistar Rats

Authors

  • Gaur T. Archana Assistant Professor

DOI:

https://doi.org/10.37506/ijop.v7i4.50

Keywords:

High-fat diet, ventromedial hypothalamus, obese rat.

Abstract

Background

Diet is one of the risk factors for obesity and VMH plays a substantial role in food intake and obesity. Food intake and body weight differ preferentially with gender. Insulin resistance, thyroid, and lipid profile are intimately linked to body metabolism. Thus, this study was conducted to assess the role of VMH on metabolism

Materials and Method

The study was conducted in the Dept. of Physiology, JIPMER after ethics committee approval. The animals were fed on HFD (total of 12 female albino Wistar rats) for a period of 10 weeks. After obtaining a basal recording of food intake, body weight, glucose, insulin, thyroid, and lipid profile for a period of 1 week, animals were divided into control and experimental subgroups (each 6 female). Experimental rats underwent electrolytic ablation of VMH whereas control rats underwent sham lesion. Then a post-lesion recording was taken for four weeks and compared between groups with appropriate statistics.

Results

VMH lesion increased food intake, body weight, blood glucose, insulin, and insulin resistance in the experimental group. VMH lesion didn't have much influence on lipid profile and thyroid profile.

Conclusion

VMH has a significant role in feeding behavior, adiposity genesis, insulin-glucose homeostasis, and lipid metabolism

Author Biography

Gaur T. Archana, Assistant Professor

Gaur T. Archana1,*, Pal G.K.2, Pal Pravati3

1Assistant Professor, Dept of Physiology, Chengalpattu Medical College, Chennai, India

2Professor (Senior Scale), Department of Physiology, JIPMER, Puducherry, India

3Professor and Head, Department of Physiology, JIPMER, Puducherry, India

Downloads

Published

2019-11-21

How to Cite

Gaur T. Archana. (2019). Effect of Ventromedial Hypothalamus on Food Intake, Body Weight, Insulin Resistance, Lipid Profile and Thyroid Profile in High-Fat Diet Obese Female Wistar Rats . International Journal of Physiology, 7(4), 27–34. https://doi.org/10.37506/ijop.v7i4.50