Status of Lipid Peroxidation and Iron Levels in Bronchial Asthma

Authors

  • Ramadevi P., A.V. Siva Kumar, K.N. Maruthy, Ch. Kiran Kumar, Sasikala P. Assistant Professor

DOI:

https://doi.org/10.37506/ijop.v7i4.87

Keywords:

Oxidative stress, Body Mass Index, Bronchial asthma, Lipid peroxidation.

Abstract

Introduction

The Oxidative stress, specifically lipid peroxidation, is believed to contribute to the pathophysiology of asthma. Low antioxidant levels and oxidative stress due to airway inflammation may be determinant of asthma severity. Level of plasma malondialdehyde (MDA) was used as index of lipid peroxidation. Even elevated iron levels also contribute for production of ROC and free radicals which causes inflammation in bronchial asthma. So the present study was aimed to reveal the relationship between lipid peroxidation and bronchial asthma.

Method

The FEV1% was measured to categorize the asthmatic patients and controls. Later MDA and serum iron levels were measured in thirty asthma cases and 30 healthy volunteers aged between 18–45 years. All the procedures were performed in the morning after their light breakfast in a less noise and illuminated room.

Results

The results showed serum MDA and iron levels significantly increased in bronchial asthmatic patients were suggestive of lipid peroxidation and oxidative stress in asthmatic patients compared to controls.

Conclusion

Therefore, Oxidative stress and lipid peroxidation are the key factors to produce ROC and free radicals which aggravates bronchial asthma.

Author Biography

Ramadevi P., A.V. Siva Kumar, K.N. Maruthy, Ch. Kiran Kumar, Sasikala P. , Assistant Professor

Ramadevi P.1, Kumar A.V. Siva2,*, Maruthy K.N.3, Kumar Ch. Kiran4, Sasikala P.3

1Assistant Professor, Dept. of Physiology, ACSR Medical College

2Faculty/Ph. D. Research Scholar, Department of Physiology, Narayana Medical College

3Professor, Department of Physiology, Narayana Medical College

4Associate Professor, Department of Physiology, Narayana Medical College, Nellore

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Published

2019-11-21

How to Cite

Ramadevi P., A.V. Siva Kumar, K.N. Maruthy, Ch. Kiran Kumar, Sasikala P. (2019). Status of Lipid Peroxidation and Iron Levels in Bronchial Asthma . International Journal of Physiology, 7(4), 183–187. https://doi.org/10.37506/ijop.v7i4.87