A Comparative Study of Pulmonary Function Tests Type 2 Diabetes Mellitus and Non-Diabetes
Keywords:T2DM & Pulmonary Function Test.
Diabetes Mellitus still remains one of the foremost causes of Morbidity and Mortality in both the developing and developed nations. Diabetes Mellitus includes a heterogenous group of hyperglycemic disorders. The presence of extensive microvascular circulation and abundant connective tissue in lungs, raises the possibility that lung tissue could be a target organ in Type2 Diabetes Mellitus
To study the effects of Type 2 Diabetes Mellitus on lung function tests.
Materials and Method
80 male subjects, 40 Type 2 Diabetes-study group, 40 Healthy-controls selected from Vaishnavi Hospital, Hyderabad. Medspiror instrument was used to record lung functions. Following parameters were recorded: Forced vital capacity (FVC), Forced Expiratory Volume in 1st sec (FEV1), FEV1/FVC ratio, Forced Expiratory Flow in middle half of FVC (FEF 25–75%) and Peak Expiratory Flow Rate (PEF). Statistical analysis was done using unpaired t-test in windows stat 9.2 software.
Study group showed statistically greater percentage reduction in FVC, FEV1, FEF 25–75% and PEF compared to control group.
Type 2 Diabetes Mellitus may be a causative factor for derangement in lung functions due to altered connective tissue, thickening of basal lamina of alveolar membrane and capillary endothelium. All these factors are leading to Restrictive Lung disorder, which exacerbate with increasing blood sugar levels and duration of Type2 Diabetes Mellitus. Therefore lung is considered as a TARGET ORGAN in Type2Diabetes Mellitus.
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