Evaluation of Reproductive Hormones in Patients with ?-Thalassemia Major in Misan Province, Iraq
DOI:
https://doi.org/10.37506/mlu.v20i2.1115Keywords:
β-thalassemia major, serum ferritin, reproductive hormones.Abstract
Assessment of serum ferritin, FSH, LH, estradiol, testosterone levels in ?-thalassemia major patients. A total
50 (30 male and 20 female) children with ?- thalassemia major patients with ages range 11- 16 years and 50
age and sex matched healthy adolescents as control group were included in this study. The study subjects
divided into 2 more subgroups: 11-13 years, and 14-16 years to measure mean serum ferritin, FSH, LH,
testosterone, estradiol hormones. There was significant increase (P <0.05) in serum ferritin level in male
and female patients as compared to control groups. Male patients have significant decreased (P<0.05)serum
levels of FSH, LH, testosterone and estradiol, while female patients have non-significant (P >0.05) high
serum FSH and testosterone levels, but LH, estradiol levels were non-significant (P>0.05) lowas compared
to control. In age subgroup 11–13 years, male patients have significant (P<0.05) decreased reproductive
hormones levels as compared to control, however in 14 – 16 years subgroups serum FSH,LH and estradiol
levels in male patients were significantly decreased as compared to control (P<0.05), whereas,hormones
levels in female patients didn’t show significant differences in comparison to female control in both age
subgroups (P>0.05). Serum ferritin had an inverse correlation with serum FSH, LH, testosterone, estradiol
hormones levels. Patients with ?- thalassemia major have iron overload with inverse correlation between
gonadal hormones and serum ferritin.
