Assessment of MR-ProADM and N-Terminal B-Type Natriuretic Peptide of Serum Levels in Patients with Heart Failure.

Abstract

Background: Heart failure timely and effective diagnosis and treatment directly affects the prognosis of

patients, so early diagnosis of heart failure treatment is very important. The current diagnosis of heart failure

has yet to be further improved. To investigate the relationship between plasma levels of MR-ProADM and

NT-proBNP in cardiac structure and function in patients with heart failure (HF) and the early detection

of failure. Methods: Patients were recruited from the coronary care unit (CCU) of Al-Yarmouk Teaching

Hospital and were admitted and verified as cases of HF by specialist cardiologists. Between the 1st of

November 2017 and the 1st of April 2018; 48 patients (29 males and 19 females), were diagnosed to have

HF and were included in the study. The total number of HF patients admitted to the CCU of the hospital

during the study period was 100 patients but 52 patients were ruled out according to the exclusion criteria of

the study such as Acute Myocardial Infarction, active myocarditis, Drug abuse or an alcohol drinker, renal

failure .Apparently healthy subjects were recruited from the staff of Al-Mustanseryeah Medicine College.

They comprised (40) subjects (30 males and 10 females). Each subject who was recruited in the control

group has underwent a full history and physical examination with a recording of : age, gender, smoking,

chronic diseases and medications.

Any subject in control group in this study must be fasting for 8-14 hours at the time of drawing of blood

specimen. Consent was taken from all subjects in the control group after being told about the aim of the

study. The plasma MR-ProADM and NT-proBNP levels were compared between the two groups to observe

the value of plasma MR-ProADM combined with NT-proBNP in the diagnosis of heart failure. Results:

the levels of plasma MR-ProADM and NT-proBNP were significantly higher in patients with heart failure

Compared with the healthy control group. The levels of plasma MR-ProADM and NT-proBNP increased

significantly (P < 0.01). The area under the ROC curve for the combined detection of plasma MR-ProADM

and NT-proBNP was greater than the area under the three alone tests. Conclusion: The combined detection

of MR-ProADM and NT-proBNP has high sensitivity and specificity in the diagnosis of heart failure and

can be used as a new detection mode.