Assessment of MR-ProADM and N-Terminal B-Type Natriuretic Peptide of Serum Levels in Patients with Heart Failure.
Keywords:MR-ProADM = mid-regional prohormone adrenomedullin, N-Terminal B-Type Natriuretic Peptide, Heart Failure .
Background: Heart failure timely and effective diagnosis and treatment directly affects the prognosis of
patients, so early diagnosis of heart failure treatment is very important. The current diagnosis of heart failure
has yet to be further improved. To investigate the relationship between plasma levels of MR-ProADM and
NT-proBNP in cardiac structure and function in patients with heart failure (HF) and the early detection
of failure. Methods: Patients were recruited from the coronary care unit (CCU) of Al-Yarmouk Teaching
Hospital and were admitted and verified as cases of HF by specialist cardiologists. Between the 1st of
November 2017 and the 1st of April 2018; 48 patients (29 males and 19 females), were diagnosed to have
HF and were included in the study. The total number of HF patients admitted to the CCU of the hospital
during the study period was 100 patients but 52 patients were ruled out according to the exclusion criteria of
the study such as Acute Myocardial Infarction, active myocarditis, Drug abuse or an alcohol drinker, renal
failure .Apparently healthy subjects were recruited from the staff of Al-Mustanseryeah Medicine College.
They comprised (40) subjects (30 males and 10 females). Each subject who was recruited in the control
group has underwent a full history and physical examination with a recording of : age, gender, smoking,
chronic diseases and medications.
Any subject in control group in this study must be fasting for 8-14 hours at the time of drawing of blood
specimen. Consent was taken from all subjects in the control group after being told about the aim of the
study. The plasma MR-ProADM and NT-proBNP levels were compared between the two groups to observe
the value of plasma MR-ProADM combined with NT-proBNP in the diagnosis of heart failure. Results:
the levels of plasma MR-ProADM and NT-proBNP were significantly higher in patients with heart failure
Compared with the healthy control group. The levels of plasma MR-ProADM and NT-proBNP increased
significantly (P < 0.01). The area under the ROC curve for the combined detection of plasma MR-ProADM
and NT-proBNP was greater than the area under the three alone tests. Conclusion: The combined detection
of MR-ProADM and NT-proBNP has high sensitivity and specificity in the diagnosis of heart failure and
can be used as a new detection mode.