Association of Terminal Complement Complex (TCC),  Prostaglandin (PGj2) among Patient with First Episode  Psychosis (Case-Control Study)

Authors

first episode psychosis, serum Complement Complex C5b-9, Prostaglandin J 2. Psychosis.

The purpose of the study investigate the association between some inflammatory biomarkers with first

episode psychosis (FEP) and to find out the correlation with different socio demographic profile. A case

control study was involve patients with first episode psychosis and healthy control. peripheral Blood samples

collected from 44 cases they were attending AL-Hakeem General hospital, Psychiatric Department, Najaf,

Iraq, in the period between January, 2019 to may, 2019. The cases included females and males, and the

age was 18-70 years. Control: 44 healthy controls who had no history or clinical evidence of first episode

psychosis or any other disease. The result revealed that increase in the level of serum Complement Complex

C5b-9 and decrease Prostaglandin J-2 among FEP patients (1021.7±58.5 and 3.82±0.36) respectively in

comparison to control were mean (585.87±47.059 and 9.94±0.67). The results of this research concluded

that, the inflammatory response is an immune system that allow the individual to cope with various menacing

advise, but in long-lasting conditions and pathological, the continuous of this stimulate could develop into

harmful. The regulation of the all development involves endogenous counter-balancing mechanisms that

control special effects of deleterious pro inflammatory mediators. information showing a misbalance in

some pro inflammatory/anti inflammatory in blood of person with FEP.

1 Lecturer in Department of Medical Microbiology, College of Medicine, University of Kufa, Najaf, Iraq, 2 Lecturer

in Department of Anesthesia Techniques, Al-Mustaqbal University College, Babylon, Iraq, 3 Assistant lecturer in

Department of Medical Microbiology, Jabir ibn Hayyan Medical University, Najaf, Iraq