Effect of Brown Algae Extract Sargassum sp on  Malondialdehyde Levels in White Rats (Rattus Norvegicus)  Pregnant Wistar Strains

Authors

Dahniar1 , Suryani As’ad2 , Nasrudin A.Mappeware3 , Gemini Alam4 , Budu5 , Rosdiana Natzir6, Burhanuddin Bahar7

Sargassum sp, Malondialdehyde, Rattus norvegicus.

Pregnancy is an inflammatory condition that produces unstable oxidative stress and can damage

macroeconomic tissue including DNA and protein which disrupt the placentation process. Increased levels

of malondialdehyde as an indicator of lipid peroxidation and decreased levels of antioxidants. This research

was conducted experimentally with pretest-posttest Control Group Design. Using three treatment groups

for the white rat (Rattus Norvegicus) test for Pregnant Wistar Strains. Twenty-one samples consisted of

three groups (Group 1 negative control, Group 2: sea algae extract Sargassum sp dose 300 mg/kg bb/day,

Group 3: sea algae extract Sargassum sp dose 600 mg/kg bb/day. Malondialdehyde levels were determined

by examination Eliza sandwich The results showed that Sargassum Sp brown algae extract had a significant

effect on decreasing levels of malondialdehyde (300mg p: 0.008 dose; 600mg p: 0.001 dose) in white rats

(Rattus norvegicus) Pregnant Wistar Strains.