Preparation & Characterization of Some Poly Ester-Amide as Drug Polymers

Abstract

In this research,lactide was synthesized by ring opening polymerization then reacted with amino

acid to obtain drug polymer,poly (ester-amide)by condensation polymerization at 90C?with mixture

DMF&dioxane(1:1),then the biodegradable polymers substituted by some hydroxyl drug units such as

3-hydroxy pyridine .The action of polymeric drugs depends on hydrolytic & cleavage of the drug moiety

from the polymer,this give advantage of late & sustained release of drug over long time with decrease of

side effects .The new polymers wich has bioactive group’s moiety were measured physical properties and

characterized by FTIR & UV spectroscopy and TG thermogram.