Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives

Authors

  • Mohammad M.Al-Tufah1 , Saad Salim Jasim2, Khalid A. Al-Badrany3

DOI:

https://doi.org/10.37506/mlu.v20i3.1597

Keywords:

Claisen 1,2-addition, chalcones, pyrazol, phenylcarbamoyl, isoindoline.

Abstract

Ten new chalcones were prepared in three steps, firstly phthalic anhydride reacted with 4- amino

acetophenone to produce 2-(4-acetyl phenyl carbamoyl) benzoic acid (A1), secondly [2-(4-acetyl phenyl

carbamoyl) benzoic acid (A1)] suffers from the loss of a water molecule via reaction with (anhydrous

sodium acetate and acetic anhydride) to produce 2-(4-acetyl phenyl) isoindoline-1,3-dione (A2), thirdly this

compound condensed with various substituted benzaldehydes affording chalcones (A3- A12) were reacted

with hydrazine hydrate to produce pyrazole compounds (A13- A22).

The prepared compounds were characterized by determination of melting point, FT-IR and some of the

prepared compounds have been characterized by (1 H-NMR and 13C-NMR) techniques.

Author Biography

  • Mohammad M.Al-Tufah1 , Saad Salim Jasim2, Khalid A. Al-Badrany3

    1 Ph.D., Student, Directorate of Education, Kirkuk, Ministry of Education, Iraq 2 Assist. Prof., Chemistry

    Department, College of Education for Pure Sciences, University of Kirkuk, Kirkuk, Iraq.

    3Prof., Dr., Chemistry Department, College of Education for Pure Sciences, University of Tikrit, Kirkuk, Iraq

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Published

2020-07-24

Issue

Vol. 20 No. 3 (2020): Medico-Legal Update

Section

Articles

How to Cite

Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. (2020). Medico Legal Update, 20(3), 1395-1399. https://doi.org/10.37506/mlu.v20i3.1597