Correlation of Ki 67, Histopathological Features and Shape of Lesionin Skeletally Mature Osteochondroma
DOI:
https://doi.org/10.37506/mlu.v20i4.1890Keywords:
Osteochondroma,proliferative marker, atypical histopathology, lesion shape, Ki 67.Abstract
Background: Osteochondroma represents the most common benign tumor of bones and accounts for
about 30-50 % of them. poor information’s in previous studies act on demonstration of the significance of
atypical histological changes as a premalignant precursor in mature osteochondroma regardless of the cap
thickness. In this study, the proliferative activity of cartilaginous cap will be studied in skeletally mature
patients regardless of the cap thickness to demonstrate the independent significant of histological features in
predicting the malignant potential in osteochondroma.
Methodology: Cases of skeletally mature osteochondroma (78 case) were isolatedand separated into sessile
and pedunculated, then into G1(without suspicious histological features) and G2 (with suspicious features),
and stained with Ki- 67 . Data were analyzed using SPSS version 21and p value < 0.05 was considered as
significant.
Results: There was significant association between study groups and Ki 67 staining results, majority (75%)
of patients with suspicious histopathological features presented with positive results of Ki 67 staining (p
value < 0.001). while there was no correlation between shape of lesion and histopathological features (p
value 0.662).
Conclusion: A typical histopathological features can be regarded as independent factor with the other
clinical data when considering the diagnosis of grade 1 chondrosarcoma.
