Study the Sensitivity and Specificity of Urinary Arginase in Bladder Cancer Patients in Babylon Governorate

Abstract

Background: Urinary Arginase is an enzyme found in the urine that can be measured by ELISA. The
sensitivity and specificity of this test can also be checked.
Aim: The present study aims to determine Arginase in urine in the bladder cancer patient’s the type of this
study is case- controls study.
Method: The study was conducted during the period from August 2019 until February 2020. There are two
groups, the first containing forty-five patients and the second forty-five control.
Results: The level of arginase in the urine of CA Bladder patients was evaluated in the two groups, the first
group, G1 newly diagnosis (94.6+17.2), and second group G2 treatment and follow-up (.91.2±13.6),compared
with normal patients control group (77.9±12.9).In this study, urinary arginase was significantly higher in
both groups of Bladder cancer patients G1 and G2 compared to normal control group of patients (CG)
P value < 0.001. In G1 (new diagnosis) urinary arginase was negligible in contrast with G2 (Treatment
and fellow up) P-value > 0.05. Throughout this analysis, the amount of urinary arginase increases with an
increase in the cancer stage, thereby increasing cell degradation and releasing more protein molecules in the
urine, such as arginase.
In Conclusion: This enzyme may serve as a useful biological urinary marker in bladder cancer while also
being an indication of the progression of bladder cancer. the sensitivity of this test (92.59) and the Specificity
(51.52)The sensitivity and specificity of this test should be improved in order to be used in the follow-up of
patients with bladder cancer