Assessment of the Relationship between Obesity and Female Breast Carcinoma in Imamein Kadhumein Medical City

Abstract

Background: Obesity, measured by body mass index (BMI), is a well-known danger feature for a widespread
variation of illnesses. Yet, in breast carcinoma (B.Ca.) the link is a little discussed and differs according to
different entities.
Aims: This study aimed to assess the relationship between obesity and breast cancer in premenopausal
women.
Subjects and Method: This is a prospective study in which 800 women who were attending breast clinic
in Al-Imamain Al-Kadhumain Medical City/Baghdad during the period from January 2016 to December
2017 were followed up for the occurrence of BCa. of these, 50 women who developed BCa during this
period were selected to represent cases group. Other 50 age-matched women who did not have BCa were
selected to represent control group. General obesity (BMI) and central obesity (waist circumference (WC),
hip circumference (HC) and waist/hip ratio (WHR)) were measured obtained from each patients either by
direct interview or from patient’s record.
Results: Demographic, reproductive and laboratory data were comparable between the two groups.
Stratification of BMI revealed significantly less cases having BMI < 25 and more having BMI>30 than
controls. Moreover, cases showed significantly higher mean of WC (84.12±6.22 cm) than controls (77.6±7.18
cm), Regarding hormonal receptor statuses, mean BMI (30.18± 9.21 kg/m2) was significantly higher in
hormonal receptor negative cases compared to 26.31±9.1 kg/m2 in estrogen and progesterone receptors
positive with significant difference. Conclusions: These data shows that obesity is a possible risk factor for
breast carcinoma in premenopausal women.