Effects of Different Antihypertensive Drugs on Systolic and Diastolic Blood Pressure, Heart Rate and Lipid Profile
DOI:
https://doi.org/10.37506/mlu.v20i4.1988Keywords:
Anti-hypertention medication, lipid profile, Heart rate.Abstract
Background : Hypertension (HTN) is a chronicmedical condition in which the systemic arterial blood
pressure is elevated. AIM OF STUDTY: The present study compared the effects of atenolol, enalapril and
amlodipine on diastolic and systolic pressure & heart rate in hypertension and effects on serum lipid were
also assessed.
Patients and Method: A total of 200 patients with hypertension and 100 normotensive controls. The
hypertensive patients were randomly allocated into three groups each of 100 patients and were treated with
either atenolol (50-100 mg) or enalapril (10-20mg) or amlodipine (5-10 mg) for three months.
Results: Patients taking atenolol showed a significant reduction of SBP, heart rate, while the group taking
enalapril showed a significant reduction of SBP, DBP, and no significant change in heart rate while with
amlodipine showed a significant decreases of SBP, DBP whereas the change in heart rate was not significant
on ther hand Amlodipine was significantly better than atenolol and enalapril at reducing total cholesterol
level. Amlodipine was significantly better than atenolol and enalapril at reducing LDL cholesterol level
.Enalapril was significantly better than amlodipine and atenolol at increasing serum HDL level . Discussion
In this study There was no significant change in heart rate in patients taking, enalapril, or amlodipine while
the heart rate was significantly reduced by atenolol. On other hand the enalapril treated group a significant
increase of HDL cholesterol. The favorable lipid changes observed with a mlodipine, a signifcant decreases
of total cholesterol and LDL cholesterol levels.
Conclusions: The systolic and diastolic BP values were significantly reduced after, atenolol, enalapril, or
amlodipine therapy . There was no significant change in heart rate in patients taking, enalapril, or amlodipine
which is consistent with that reported else On the other hand heart rate was significantly reduced by atenolol
. on other hand amlodipine are to be preferred in hypertensive patients with elevated LDL-cholesterol levels
and enalapril is valuable in hypertensive patients with low HDL-cholesterol levels.
