Major Adverse Cardiovascular Events in Patients Starting Peritoneal Dialysis Based on the CKD-EPI Versus Thai eGFR Equation: A Retrospective Cohort Study

Authors

  • Nathaphop Chaichaya1 , Bandit Thinkhamrop2 , Sajja Tatiyanupanwong3 , Katharine Morley4 , Michael Morley5 , Wilaiphorn Thinkhamrop6 , Wongsa Laohasiriwong7

DOI:

https://doi.org/10.37506/mlu.v20i4.2096

Keywords:

Late stage, end stage kidney disease, PD, CVD, advanced stage, CKD.

Abstract

Background: Major adverse cardiovascular events (MACE) are the leading cause of deathin chronic kidney
disease (CKD) patients. The relationship between the initiation of peritoneal dialysis (PD) and MACE is
unclear.
Objective: This study compared the incidence of MACE in PD patients when the estimated- glomerular
filtration rate (eGFR) is calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation with the Thai eGFR equation.
Method: The study was conducted among 684 end-stage CKD patients in a referral hospital in Thailand
between 2011-2018. The first occurrence of cardiovascular events related MACE was defined as dependent
variable. Logistic regression was used to identify the relationship.
Results: The incidence of MACE was different between CKD-EPI group (10.9%) and Thai eGFR group
(12.4%). After adjusting for other factors, the PD initiation using eGFR calculated by CKD-EPI equation
did not affect the incidence of MACE when compared to those from Thai eGFR equation (Ajd.OR: 1.11;
95%CI: 0.68-1.82, P-value = 0.685).
Conclusion: There was no effect on incidence of MACE when PD was initiated based on eGFR calculated
using the CKD-EPI equation compared with the Thai eGFR equation.

Author Biography

  • Nathaphop Chaichaya1 , Bandit Thinkhamrop2 , Sajja Tatiyanupanwong3 , Katharine Morley4 , Michael Morley5 , Wilaiphorn Thinkhamrop6 , Wongsa Laohasiriwong7

    1Doctor of Philosophy in Epidemiology and Biostatistics (International Program), Faculty of Public Health,
    KhonKaen University, Thailand. 2
    Associate Professor, Department of Biostatistics and Demography, Faculty of
    Public Health, KhonKaen University, Thailand, 3Nephrologist, Kidney Unit, Department of Internal Medicine,
    Chaiyaphum Hospital, Chaiyaphum, Thailand, 4Internal Medicine Specialist, Department of Medicine,
    Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, 5Ophthalmologist, Department
    of Ophthalmology, Harvard Medical School, Boston, MA, USA, 6
    Statistician, Data Management and Statistical
    Analysis Center, Faculty of Public Health, KhonKaen University, Thailand, 7Associate Professor, Faculty of Public
    Health, KhonKaen University, Thailand

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Published

2020-11-18

Issue

Vol. 20 No. 4 (2020): Medico-Legal Update

Section

Articles

How to Cite

Major Adverse Cardiovascular Events in Patients Starting Peritoneal Dialysis Based on the CKD-EPI Versus Thai eGFR Equation: A Retrospective Cohort Study. (2020). Medico Legal Update, 20(4), 1763-1770. https://doi.org/10.37506/mlu.v20i4.2096