The Effect of Hypokalemia on Early-onset Peritoneal Dialysis-related Peritonitis
DOI:
https://doi.org/10.37506/mlu.v20i4.2098Keywords:
First episode of peritonitis, hypokalemia, EOPAbstract
Background: Early-onset peritoneal dialysis-related peritonitis (EOP) increased technique failure and
mortality among peritoneal dialysis (PD) patients. However, whether hypokalemia is the risk of EOP
remains unclear.
Objective: This retrospective cohort study aimed to identify the association between hypokalemia within
the first 3 months after PD initiation and EOP.
Method: A total of 947 PD patients registered at the Kidney Unit in Chaiyaphum regional hospital from
January 2011 to December 2018 were recruited and followed up. The first EOP episode within 6 months
after the initiation of PD was a primary outcome. Logistic regression was used to identify the association.
Results: Of the total,485 experienced hypokalemia. 90 patients, developed EOP, 61 were from the
hypokalemic group (12.6%). Hypokalemia was a significant risk factor of EOP (OR, 2.36; 95% CI, 1.42 to
3.94; P=0.01), as well as decreased serum bicarbonate level (OR, 0.90; 95%CI, 0.82 to 0.99; P=0.026) and
decreased hemoglobin level (OR, 0.72; 95% CI, 0.57 to 0.90; P=0.004) and elevated sodium (OR, 1.07;95%
CI, 1.00 to 1.15; P=0.046) while controlling other covariates.
Conclusions: Hypokalemia within the first three months after PD initiation was a significant risk factor of
EOP.
