Helicobacter Pylori-Associated Iron-Deficiency Anemia and Interleukins Effect

Abstract

Helicobacter pylori (H. pylori) is a highly prevalence microbial infection, that acts as an iron stressor in
susceptible individuals the relationship between ferritin and cytokine levels in individuals infected with H.
pylori remains controversial. Based on serology testing for anti-H. pylori IgG, participants (70 seropositive
and 70 seronegative aged 30-60 years were enrolled. Serum iron profiles including iron, ferritin, and total
iron-binding capacity, were measured. IL-1? and IL-6 serum levels were compared. The mean value of
interleukin 1beta (IL-1?) level of patients and controls revealed that H. pylori patients had a significantly
higher at (P< 0.001) mean of (IL-1?) when compared to the controls, as shown in this study there is positive
correlation between gastric interleukin 1beta (IL-1?) and iron deficiency anemia (IDA) blood parameters
observed in resent study could be due to the powerful capability of IL-1? in inhibiting gastric acid secretion.
The mean value of Interleukin-6 (IL-6)) level of patients and controls revealed that H. pylori patients had a
significantly higher at (P< 0.001) mean of (IL-6) when compared to the controls.