Cassava Leaves Extract (Manihot esculenta) Prevents the Decrease of Albumin Serum Level in Mice with GentamicinInduced Hepatotoxicity

Abstract

Gentamicin is effectively used for the treatment of gram-negative bacterial infection but it has a hepatotoxic
effect. Lipid peroxidation and suppression of endogenous antioxidants by gentamicin increases the
production of reactive oxygen species which leading to necrosis ofhepatocyte. Cassava leaves (Manihot
esculenta) contain phenolic compounds, flavonoids, vitamin C, carotene, and iron which act as antioxidant
and enzymatic antioxidant cofactor which can inhibit lipid peroxidation. This research aimed to determine the
influence of cassava leaves extract to serum albumin level in mice with gentamicin-induced hepatotoxicity.
Mice were divided into groups N, K (gentamicin 80 mg/kg b.w.); P1, P2, P3 (gentamicin 80 mg/kg b.w. and
cassava leaves extract 150 mg/kg b.w., 300 mg/kg b.w., 450 mg/kg of b.w. for 14 days). Serum albumin level
in group K was decreased compared to group N; group P1, P2, P3 were respectively gradually increased.
One Way Anova analysis showed significant difference among groups (p<0.05). Post Hoc Tukey test showed
that serum albumin level in group P3 was significantly different from group K (p<0.05). It can be concluded
that cassava leaves extract prevent the decrease of serum albumin level in mice with gentamicin-induced
hepatotoxicity