An Analytical Prospective Study of Plasma Pseudo– Cholinesterase Level & its Co-Relation to Mortality in Acute Organo Phosphate Poisoning

Abstract

Background: The Incidence of Poisoning Is Constantly On The Rise In The Modern World With A Gradual
Shift Towards The Use of Agricultural Poisons In Suicides With Majority of Cases Using Organophosphate
Compounds And In India The Incidence of Ingested Suicidal Poisoning Is High Especially In The Southern
States. This Study Is Undertaken With A View To Asses If There Is Any Correlation Between Plasma Levels
of Pseudocholinesterase and mortality in cases of acute organophosphate poisoning. Method: The study was
conducted on patients of organophosphate poisoning admitted to Bapuji Hospital (J.J.M. Medical College),
Davangere during a period of October 2011 to March 2013. Total number of cases studied were 150. Detailed
history was obtained regarding the amount of poison, type of poison, quantity of poison, etc from the patient
and his/her relatives as well from the police.
Clinical examination of each patient was carried out and according to signs and symptoms, the patients were
grouped into 3 grades, mild, moderate and severe according to Dreisbach’s criteria. At the time of admission
pseudocholinesterase was measured. All patients were followed-up for 3 days to know the outcome and
results were compared and analysed.
Conclusion: Our study concludes that there is a very good correlation between the levels of plasma
pseudocholinesterase and mortality as well as morbidity