The Proteomic Expression of Nuclear Apoptosis-Inducing Factor1 (NAIF1) in Colorectal Tissues
Keywords:DNA transposons, Domestication, Neogene, NAIF1, microsatellite instable, microsatellite stable, colorectal cancer.
The neogenic recombinases are potentially a source of genetic variability possibly implicated in the
mechanisms of genetic instability involved in the processes of carcinogenesis. One of these neogenic
recombinases is the nuclear apoptosis-inducing factor 1(NAIF1), which codes the protein NAIF1 that
induces apoptosis in various human cancers.
The aim of this work is to study the expression of NAIF1 neogene in cancerous and non-cancerous colorectal
The protein expression of NAIF1gene has been studied by western blot method in the samples of protein
extracted from 29 patients with colorectal cancer.
The result of this study showed that the protein expression of NAIF1 was found in both cancerous and
non-cancerous colorectal tissues, but it is highly expressed in non-cancerous tissues adjacent to cancerous
one. Its expression is higher in non-metastatic cancerous tissues compared with metastatic one. Also this
expression is higher in microsatellite instable (MSI) group of cancer compared with microsatellite stable
It can be concluded that NAIF1 protein expression inversely related with more advanced stage or grade of
colorectal cancer and it may have a role in inhibition of proliferation, migration and invasion of colorectal
cancer by inducing apoptosis.
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