Evidence Based of Effects and Protection Mechanism of Lycium Barbarum Polysaccharide on Ethanol-Induced Liver Injury


  • Alshaimaa Abdelkhaliq Mohammad Farrag
  • Abeer Elsayed Mohamed Aatia
  • Walaa Fawzy Mohammed Zaher




L. barbarum polysaccharides (LBP) - ethanol-induced injury - drugs-induced liver injury - reactive oxygen species (ROS).


Excessive ethanol intakes have been reported to be linked to liver diseases such as hepatitis and cancerrelated diseases of ethanol. Excessive ethanol can lead to the accumulation of reactive oxygen species
(ROS) and to the depletion of glutathione (GSH) in the liver. Ethanol-induced oxidative stress substantially
increases peroxidation of the lipid and decreases GSH levels in human hepatocyte and animal models.
Ethanol contributes to sterol regulating element-binding protein activation (SREBP)-1 by regulating main
genes such as Acetyl-CoA carboxylase (ACC) and Stearoyl-CoA desaturase 1(SCD1) to facilitate lipid
accumulation in the liver. The liquid fraction derived from wolfberry is lycium barbarum polysaccharide
(LBP). In many animal disease models, it is an effective antioxidant and tissue protective agent. Researchers
have shown hepato-protective functions in acute hepatic injury, NAFLDs, drugs-induced liver injury and
hepatocellularcarcinoma models. The protection effect of L. barbarum polysaccharides (LBP) in this study
on ethanol-induced injury in human hepatocytes was explored. In addition, the influence of LBP on oxidative
stress protein activity was examined.

Author Biographies

Alshaimaa Abdelkhaliq Mohammad Farrag

Assistance Professor, College of Medicine, University of Bisha, Saudi Arabia

Abeer Elsayed Mohamed Aatia

Assistance Professor, Faculty of
Applied Medical Science, University of Bisha, Saudi Arabia

Walaa Fawzy Mohammed Zaher

Assistance Professor,College of Science and Arts,
University of Bisha, Saudi Arabia



How to Cite

Alshaimaa Abdelkhaliq Mohammad Farrag, Abeer Elsayed Mohamed Aatia, & Walaa Fawzy Mohammed Zaher. (2021). Evidence Based of Effects and Protection Mechanism of Lycium Barbarum Polysaccharide on Ethanol-Induced Liver Injury. Medico Legal Update, 21(2), 110-119. https://doi.org/10.37506/mlu.v21i2.2656

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