Physiological and Molecular Study of Iraqi Women with Polycystic Ovary Syndrome
Keywords:Ovary, Testosterone, gene, polycystic, polymorphism, Insulin resistance
Polycystic ovary syndrome is define as illness in women that a reproductive age because common
endocrinopathy and lead to reproductive dysfunction also infertility. PCOS is usually alignment with
insulin resistance and metabolic syndrome, it is think that PCOS is the outcome of genetic effect addition
to ecological factor. In this study (100) samples which divided into 40 samples of heath women and 60
samples of women with PCOS. It diagnosed by ovarian morphology on ultrasound also test the fasting blood
sugar, insulin, insulin resistance and testosterone hormone by biochemical method also used molecular
method to detect the genotype of TCF4 gene (rs290487) by RFLP-PCR technique. The results revealed that
the frequency of allele T was recorded a highly significance (P<0.01) in patients (0.81%) while in control
(0.89%), the frequency of allele C allele significant (P<0.01) in patients (0.19%) while in control (0.11%).
We can be concluded from this study that the genetic variation in Iraqi women of gene (TCF4) was linked
with PCOS while contrary in control (healthy women).
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