Association of Genetic Polymorphism of Insulin Receptor Substrate 1 (IRS-1) with Polycystic Ovary Syndrome Pathogenicity in Iraqi Women
Keywords:Polycystic Ovary Syndrome, Pathogenicity, Genetic Polymorphism, Insulin Receptor Substrate 1
Background: Insulin receptor substrate 1 (IRS-1) is an intracellular signaling adapter protein that integrates
and coordinates multiple biologically key extracellular signals within the cell, is also a key central receptor
in insulin signaling, and plays a focal role in maintaining essential cellular capabilities, e.g., survival,
development and digestion system. IRS1 is essentially found in the cytoplasm But localization in nucleus
may occur in some cell types and under certain stimuli.
Materials and Method: A total of 104 healthy control and 215 Iraqi women have Polycystic ovary syndrome
(PCOS) aged 20–40 years who was admitted to conducted a prospective clinical study at kerbala gynecology
teaching hospital, it was measured the genotype distribution of the rs2943641 T to C substitution of IRS1
and the effects of genotypes on Polycystic Ovary syndrome Pathogenicity in Iraqiwomen,
Results: Analyses were conducted to assess the association between the SNP rs2943641 [TT (Wild type),
TC (heterozygous type), and CC (mutated type)], with the pathogenesis of PCOS according to logistic
regression results. This survey demonstrated that there was no significant association between different
alleles for this SNP with the pathogenesis of PCOS
Conclusion: Genetic polymorphism with IRS-1may be associated with metabolic disturbance but not
Polycystic Ovary syndrome in Iraqiwomen.
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