Mutans Streptococci Count and Salivary Histatin 5 Level in Relation to Early Childhood Caries
Keywords:Early childhood caries, Mutans streptococci, histatin 5.
Background: ECC is one of the most common chronic infectious diseases of preschool-aged children (3).
Mutans Streptococci (MS) is the cheif microorganism that causes ECC Saliva is a significant factor in the
development of teeth decay. Saliva have many innate defense molecules that take part in the protection of
oral tissues by either direct antimicrobial effect or interference with microbial colonization. These molecules
include antimicrobial peptides AMPs among the main natural antimicrobial proteins of saliva . Salivary
histatine-5 (HST-5) is one of the protective factors in saliva that possess anti-bacterial properties against
several types of oral bacter. This study aimed to measure the viable count of mutans streptococci and salivary
histatin 5 level in relation to early childhood caries.
Materials and Method: Sixty three children with ages of 4-5 years old were enrolled in this study. They
were divided into two groups; 33 children with severe type of ECC) ategory as the study group and 30 caries
free child) as the control group. Unstimulated saliva sample were collected for ms count on mitis bacitracin
agar and for evaluation of salivary Histatin 5 level.
Results: Statistical analysis revealed that M.S. count was higher significantly in study group compared to
than control group and salivary histatin 5 was significantly higher than the control group.
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