Diuretics increase Blood Creatinine in the Treatment of Hypertension

Abstract

Background: Diuretics have been used in the treatment of hypertension by either alone or combining it
with other antihypertensive drugs. It treated about 50% of hypertensive patients alone and about 80% when
treatment was a combination with other antihypertensive drugs. Oral diuretics are used as an initiating
antihypertensive treatment in stepped care approach the antihypertensive management .One such loop diuretic
called as Furosemide is being regularly used in different stages of acute kidney injury and hypertension.
Lowering the blood pressure is ultimately reducing the risk of cardiovascular morbidity and mortality. The
sideeffects of diuretics are dose dependent. The intake of Furosemide will bring an increase in the creatinine
level.It must be noted that if the diuretics are been taken for prolong usage, it might over-stress the function
of kidney which will result in sodium resorption increase and elevation of creatinine levels.
Material and Method: Twenty hypertensive patients in the age range of 40 to 76 years old were subjected
to a treatment with furosemide(20mg/day) for a variable period of one to three years. The analysis of blood
samples was being done against the serum creatinine following the colorimetric method. The results were
statistically processed and analyzed by SPSS using the T-test method.
Results: The trial was runon the participants being either hypertensive patients or normal individuals. The
Mean (+/-SD) of age was 59.4 +/- 10.3, mean (+/-SD) of duration of treatment with furosemide was 2.1 +/-
0.7. Mean (+/-SD) of serum creatinine in the control individual was 0.9 +/- 0.22, and mean serum creatinine
in hypertensive patients treated with furosemide was 2.37 +/- 0.69. (P value < 0.05.)
Conclusion: The diuretic Furosemide can increase thelevel of creatinine.
Aim of the work: Determine the effect of diuretics (furosemide) on serum creatinine.