Evaluation of Ischemia Modified Albumin IMA as New Predictor in Patients with Newly Thyroid Dysfunction in Type 2 Diabetes Mellitus
Keywords:Type2 DM,thyroid dysfunction,ischemia modified albumin.
In the general population Thyroid dysfunctions are common after DM as the most well-known situation to
influence the endocrine system. Diabetic patients are at increased danger of thyroid sickness, particularly
persons with poor glycaemic control. Ischemia Modified Albumin IMAis novel marker of oxidative stress and
tissue ischemia . The pathophysiological occasions of ischemia, including free oxygen radicals and hypoxia,
bring about a conformational change of albumin in the N-terminus. The study included 120 subjects, divided
into four groups; the first group included 30 patients type2 diabetes mellitus T2DM with newly diagnosed
hyperthyroidism HprT, the second group includes 30 patients T2DMwith newly diagnosed hypothyroidism
HpoT, the third group included 30 patients diagnosed with T2DM, and the fourth group included 30 healthy
control subjects. The concentration of (fasting blood glucose FBG, Glycated hemoglobin HbA1c,Total
cholesterol TC, Triglyceride TG,high density lipoprotein HDL, Free Triiodothyronin FT3,Free Thyroxin
FT4 and thyroid-stimulating hormone TSH). The results show high significant differences in level of IMA
between all studied groups that including diabetic patient with newlydiagnosed hyperthyroidism, diabetic
patient with newlydiagnosed hypothyroidism, DM only, and control group [(2.60±1.11), (2.41±1.23),
(2.57±5.50), (2.10±0.61)] respectively.
Conclusion: Biomarkers IMA could be helpful early diagnosis in monitoring T2DM with newlydiagnosed
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