Serum Podocalyxin Levels as High Risk Markers for CVDs of Complication of Diabetes
Keywords:Diabetes mellitus, glycaemiaindices, insulinresistance, podocalyxin.
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in
insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term
damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood
vessels; Podocalyxin is the major sialoprotein in the glycocalyx of glomerular podocytes, podocalyxin was
found in the blood vessels of several organs.
Objective: The aim of the present study was to elevate serum podocalyxin and some biochemical parameters
in diabetic patients compare with healthy group.
Method: The present case-control study included 90 participants divided into two groups: 60 patients with
diabetes mellitus (40 males and 20 females; aged 49.87 ±8.089 yr.) study group and 30 (20 males and
10 females; aged 48.27±6.335 yr.) a healthy group (control group). Podocalyxin (PODXL) and insulin
measured using the ELISA kit. Anthropometric were measured fasting serum glucose levels and lipid profile
were determined by photometric method.
Result: The mean serum podocalyxin levels was significantly increase in patients with diabetes mellitus Vs.
healthy control group (26.24±2.11ng\ml Vs. 17.45±1.57ng\ml respectively, p<0.001), BMI was significantly
increased in patients diabetes mellitus Vs. healthy control group (29.766±3.225 Vs. 23.756±0.77 respectively,
p<0.001) also the mean fasting insulin level was higher in patients with diabetes mellitus than the healthy
control group (7.23±1.26 Vs. 5.05±1.14 respectively, p<0.001), HOMA-IR significantly increased in
patients with diabetes mellitus Vs. healthy control group (2.65±0.77 Vs. 1.16±0.25 respectively, p<0.001)
but the mean of HOMA-? in patients with diabetes mellitus was significantly lower than the healthy control
group (35.30±13.83 Vs. 61.91±19.87 respectively, p<0.001), lipid profile include TG, TC, LDL-C, VLDL-C
significant increased in patients with diabetes mellitus compared with healthy control group (211.50±88.02
Vs. 116.87±38.43, p<001), (240.13±56.20 Vs. 141.43±33.34, p<0.001), (161.87±56.39 Vs. 65.82±30.97,
p<0.001), (42.30±17.60 Vs. 23.37±7.68, p<0.001) respectively except HDL-C were significantly decreased
in patients with diabetes mellitus than the healthy control group (33.83±9.02 Vs. 52.23±7.08 respectively,
p<0.001), Patients with diabetic mellitus have significantly higher serum podocalyxin levels than the
controls. Podocalyxin levels positively significantly correlated with BMI, FSG, Insulin, HbA1c and HOMAIR levels while HOMO-? significant negative correlation respectively with podocalyxin levels. podocalyxin
may be a promising biomarker in patients with diabetes mellitus.
Conclusion: Podocalyxin may be a promising biomarker in patients with diabetes mellitus and can be used
as a high risk markers for CVDs in DM patients.
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