Association of Thyroid Function with Metabolic Parameter in IDD Clinic Patients, Magelang Research and Development Center

Abstract

Metabolic parameters, such as lipid and glucose metabolism, blood pressure, and body weight, are influenced
by thyroid hormones. Thyroid dysfunction may lead to the development of the metabolic syndrome. The
study aimed to analyze the relationship between thyroid dysfunction and metabolic parameters in IDD clinic
patients, Magelang Research and Development Center. A cross-sectional study of 83 patients who met the
inclusion and exclusion criteria. Total cholesterol, LDL, HDL, TSH, and free T4 concentration had been
measured in all subjects. BMI and blood pressure were measured. Concentrations of lipids, triglycerides,
free T4, and TSH were analyzed. The mean age of the patient was 33.5 ± 8.6 of whom 6 (7.2 %) subclinical
hypothyroidism, 17 (20.5 %) overt hyperthyroidism, and 17 (20.5 %) had subclinical hyperthyroidism. There
was positive relationship between TSH and systolic; whereas, FT4 was associated with BMI, systole, and
diastole after adjustment for age. Overt hyperthyroidism had significantly higher odds of hypertension after
adjustment for age and BMI (OR 5.557 (1.310-23.578), p<0.05). Hyperthyroidism may induce hypertension.