Lungs’ Microscopic Patterns of Vessels in Patients Deceased with or by SARS-CoV-2 Infection

Authors

  • Francesco Lupariello
  • Francesca Vairano
  • Giuliana Mattioda
  • Federica Mirri
  • Alessandro Gabriele
  • Giancarlo Di Vella

DOI:

https://doi.org/10.37506/mlu.v21i3.2998

Keywords:

COVID19; endothelium; forensics; lung parenchyma; pathology;SARS-CoV-2; vessels

Abstract

Background: even if specific mechanisms are not completely understood, several studies highlighted Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) ability to alter vascular homeostasis. In the
literature, multiple reports of microscopic pulmonary findings of vascular structures in patients deceased by
or with SARS-Cov-2 infection are available. Nevertheless, the scientific literature lacks a systematic analysis
of these findings. Methods: the authors realized a systematic review of the literature in order to identify
common microscopic patterns representative of pulmonary vascular damage: useful data for pathologists in
clinical and forensic settings. The research yielded 23 articles (79 total cases). Quali/quantitative analysis
was carried out. Conclusion: the review allowed to identify vascular thrombosis (especially in lesser caliber
vessels) as common microscopic pattern. The recurrence of this pattern was confirmed by scientific literature
data which demonstrate SARS-CoV-2 ability to interfere with coagulation cascade. Other meaningful
microscopic findings were also discussed, even if their low frequency in study population did not allow to
define them as common.

Author Biographies

Francesco Lupariello

Scientist ,Department of Public Health Sciences and Pediatrics –Medico-Legal Unit - “University of Turin”; address: corso Galileo Galilei 22, 10126 Torino, Italy

Francesca Vairano

Scientist ,Department of Public Health Sciences and Pediatrics –Medico-Legal Unit - “University of Turin”; address:corso Galileo Galilei 22, 10126 Torino, Italy

Giuliana Mattioda

Scientist ,Department of Public Health Sciences and Pediatrics –Medico-Legal Unit - “University of Turin”; address: corso Galileo Galilei 22, 10126 Torino, Italy

Federica Mirri

Scientist ,Department of Public Health Sciences and Pediatrics –Medico-Legal Unit - “University of Turin”; address: corso Galileo Galilei 22, 10126 Torino, Italy

Alessandro Gabriele

Scientist ,Department of Public Health Sciences and Pediatrics –Medico-Legal Unit - “University of Turin”; address:corso Galileo Galilei 22, 10126 Torino, Italy

Giancarlo Di Vella

Full ProfessorDepartment of Public Health Sciences and Pediatrics –Medico-Legal Unit - “University of Turin”; address:corso Galileo Galilei 22, 10126 Torino, Italy

Published

2021-06-03

How to Cite

Lupariello, F. ., Vairano, F. ., Mattioda, G. ., Mirri, F. ., Gabriele, A. ., & Vella, G. D. . (2021). Lungs’ Microscopic Patterns of Vessels in Patients Deceased with or by SARS-CoV-2 Infection. Medico Legal Update, 21(3), 280-291. https://doi.org/10.37506/mlu.v21i3.2998

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