Correlation between HS-CRP in Serum with Neurological Deficit Measured by Nihss in Acute Ischemic Stroke
Keywords:CRP, hs-CRP, NIHSS, acute ischemic stroke.
Background: CRP can increase the regulation of adhesion receptors on endothelial cells which can lead to
infiltration of neutrophil and monocyte cells to endothelial cells. This causes endothelial cell damage and
blood brain barrier dysfunction eventually leading to brain cell death. This brain cell death will result in
impaired brain function and affect the severity of the stroke. The problem that arises is whether there is a
correlation between CRP levels in serum and the severity of acute ischemic stroke as measured by NIHSS.
Method: Sixty patients with acute thrombotic stroke who were treated at the neurology ward of Dr.Soetomo
General Hospital (a Teaching Hospital of Faculty of Medicine, Universitas Airlangga) during June-September
2019 had serum levels of CRP measured with sandwich ELISA method using high sensitivity CRP (hs-CRP)
and neurological deficit was assessed using the NIHSS.
Result: Mean age of subjects was 57,45±8,89 years. The study subjects consisted of 37 male and 23 female.
The median serum levels of hs-CRP is 0,4 mg/dL with a range of 0,1-15,1 mg/dL. Median NIHSS is 5 with
a range of 2-15. There is a positive correlation with moderate correlation strength between serum levels of
hs-CRP and the NIHSS value in patients with acute thrombotic stroke and statistically significant (p=0.000,
Conclusion: There is a moderate positive correlation between serum levels of hs-CRP and neurological
deficit measured by NIHSS.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.