Lungs’ Microscopic Patterns of Vessels in Patients Deceased with or by SARS-CoV-2 Infection

Authors

  • Francesco Lupariello
  • Francesca Vairano
  • Giuliana Mattioda
  • Federica Mirri
  • Alessandro Gabriele
  • Giancarlo Di Vella

DOI:

https://doi.org/10.37506/mlu.v21i4.3119

Keywords:

COVID19; endothelium; forensics; lung parenchyma; pathology;SARS-CoV-2; vessels

Abstract

Background: Even If Specific mechanisms are not completely understood, several studies highlighted
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) ability to alter vascular homeostasis.
In the literature, multiple reports of microscopic pulmonary findings of vascular structures in patients
deceased by or with SARS-Cov-2 infection are available. Nevertheless, the scientific literature lacks a
systematic analysis of these findings. Methods: the authors realized a systematic review of the literature in
order to identify common microscopic patterns representative of pulmonary vascular damage: useful data
for pathologists in clinical and forensic settings. The research yielded 23 articles (79 total cases). Quali/
quantitative analysis was carried out. Conclusion: the review allowed to identify vascular thrombosis
(especially in lesser caliber vessels) as common microscopic pattern. The recurrence of this pattern was
confirmed by scientific literature data which demonstrate SARS-CoV-2 ability to interfere with coagulation
cascade. Other meaningful microscopic findings were also discussed, even if their low frequency in study
population did not allow to define them as common

Author Biographies

Francesco Lupariello

Researcher and Assistant Professor,  Department of Public Health Sciences and
Pediatrics –Medico-Legal Unit - “University of Turin”; Corso Galileo Galilei 22, 10126 Torino, Italy

Francesca Vairano

Scientist, Department of Public Health Sciences and
Pediatrics –Medico-Legal Unit - “University of Turin”; Corso Galileo Galilei 22, 10126 Torino, Italy

Giuliana Mattioda

Scientist, Department of Public Health Sciences and
Pediatrics –Medico-Legal Unit - “University of Turin”; Corso Galileo Galilei 22, 10126 Torino, Italy

Federica Mirri

Scientist, Department of Public Health Sciences and
Pediatrics –Medico-Legal Unit - “University of Turin”; Corso Galileo Galilei 22, 10126 Torino, Italy

Alessandro Gabriele

Full Professor, Department of Public Health Sciences and
Pediatrics –Medico-Legal Unit - “University of Turin”; Corso Galileo Galilei 22, 10126 Torino, Italy

Giancarlo Di Vella

Full Professor, Department of Public Health Sciences and
Pediatrics –Medico-Legal Unit - “University of Turin”; Corso Galileo Galilei 22, 10126 Torino, Italy

Published

2021-08-27

How to Cite

Francesco Lupariello, Francesca Vairano, Giuliana Mattioda, Federica Mirri, Alessandro Gabriele, & Giancarlo Di Vella. (2021). Lungs’ Microscopic Patterns of Vessels in Patients Deceased with or by SARS-CoV-2 Infection. Medico Legal Update, 21(4), 140-149. https://doi.org/10.37506/mlu.v21i4.3119

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