Correlation between Fibrinogen Level with Middle Cerebral Artery Pulsatility Index in Acute Ischemic Stroke

Abstract

Background: High levels of fibrinogen will increase the blood viscosity. Pulsatility index parameter in
transcranial doppler can measure blood vessel resistance which influence by cerebral blood flow velocity
and blood viscosity. This study has aim to find correlation between fibrinogen with PI in acute thrombotic
stroke patient.
Method: A cross sectional design was used in this study. The samples were patient with acute ischemic stroke
in neurological ward Dr. Soetomo Hospital Surabaya from January 2019 to December 2020. Fibrinogen
level was measured using clauss method. PI was calculated by peak systolic velocity, end diastolic velocity
and mean vessel velocity, which were measured in middle cerebral artery.
Result: This study involved 32 samples consisted 22 males and 10 females. Mean age of subjects was
55.37 ± 10.55. The mean fibrinogen level is 356.95 ± 139.57. Mean MCA PI is 1.03 ±0.34. There is positive
correlation with weak correlation strength between fibrinogen level with MCA PI in acute thrombotic stroke
patients and statistically significant (p=0.024, r=0.398).
Conclusion: There is a positive correlation between fibrinogen level with PI MCA in acute thrombotic
stroke.