Correlation between Fibrinogen Level with Middle Cerebral Artery Pulsatility Index in Acute Ischemic Stroke

Authors

  • Rika Ainun Tikha
  • Sita Setyowatie
  • Muhammad Hamdan
  • Achmad Firdaus Sani
  • Mohammad Saiful Ardhi

DOI:

https://doi.org/10.37506/mlu.v21i4.3145

Keywords:

acute ischemic stroke, fibrinogen, MCA PI

Abstract

Background: High levels of fibrinogen will increase the blood viscosity. Pulsatility index parameter in
transcranial doppler can measure blood vessel resistance which influence by cerebral blood flow velocity
and blood viscosity. This study has aim to find correlation between fibrinogen with PI in acute thrombotic
stroke patient.
Method: A cross sectional design was used in this study. The samples were patient with acute ischemic stroke
in neurological ward Dr. Soetomo Hospital Surabaya from January 2019 to December 2020. Fibrinogen
level was measured using clauss method. PI was calculated by peak systolic velocity, end diastolic velocity
and mean vessel velocity, which were measured in middle cerebral artery.
Result: This study involved 32 samples consisted 22 males and 10 females. Mean age of subjects was
55.37 ± 10.55. The mean fibrinogen level is 356.95 ± 139.57. Mean MCA PI is 1.03 ±0.34. There is positive
correlation with weak correlation strength between fibrinogen level with MCA PI in acute thrombotic stroke
patients and statistically significant (p=0.024, r=0.398).
Conclusion: There is a positive correlation between fibrinogen level with PI MCA in acute thrombotic
stroke.

Author Biographies

Rika Ainun Tikha

Resident Student, Division of Neurovascular, Department of Neurology,  Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga,
Surabaya, Indonesia

Sita Setyowatie

Lecturer, Division of Neurovascular, Department of Neurology, Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga,
Surabaya, Indonesia

Muhammad Hamdan

Lecturer Division of Neurobehaviour, Department of Neurology, Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Achmad Firdaus Sani

Lecturer, Division of Neurovascular, Department of Neurology, Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga,
Surabaya, Indonesia

Mohammad Saiful Ardhi

Lecturer, Division of Neurovascular, Department of Neurology, Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga,
Surabaya, Indonesia

Published

2021-08-27

How to Cite

Rika Ainun Tikha, Sita Setyowatie, Muhammad Hamdan, Achmad Firdaus Sani, & Mohammad Saiful Ardhi. (2021). Correlation between Fibrinogen Level with Middle Cerebral Artery Pulsatility Index in Acute Ischemic Stroke. Medico Legal Update, 21(4), 296-300. https://doi.org/10.37506/mlu.v21i4.3145