Determination of Total Flavonoid Content and Initial Test of Anticancer Activity of Faloak Leaves and Fruit Extracts (Sterculia urceolata Smith)

Abstract

This study aimed to determine the total flavonoid content and anticancer activity of Faloak (Sterculia
urceolata Smith) leaves and fruit extracts. Brine Shrimp Lethality Test (BSLT) method determined
the anticancer activity. Testing the total flavonoid content of n-hexane extract of the Faloak leaves
and fruit were 1558.5 and 498.5 ppm, respectively. The total flavonoid content of the ethyl acetate
extract of Faloak leaves and fruit were 876.5 and 621.8 ppm, respectively. The ethanol extract of Faloak
leaves and fruit’s total flavonoid content was 338.5 and 1688.5 ppm. The anticancer activity test of
the n-hexane extract of Faloak leaves and fruit showed that each extract’s LC50 value was 31.417
and 50.736 ppm, respectively, and the LC50 value ethyl acetate extract of Faloak leaves and fruit were
119.68 and 77.59 ppm. The LC50 value of ethanol extract of Faloak leaves and fruit were 43.82 and
20.779 ppm, respectively. Both the leaves and fruit extract of Faloak had strong anticancer activity
(<1000 ppm). However, the extracts with the strongest anticancer activity were the ethanol extract of
Faloak fruit and the n-hexane extract of Faloak leaves. Meanwhile, the extract with the highest amount
of flavonoid content was the ethanol extract of Faloak fruit (1688.5 ppm), and the lowest amount was
ethanol extract of the Faloak bark (4.5 ppm).