Green-Blue Discolouration of Brain at Autopsy: A Case Report

Authors

  • Saritha S R
  • Greeshma C K
  • Sreedevi C S

DOI:

https://doi.org/10.37506/mlu.v22i4.3335

Keywords:

Acute liver failure, liver transplantation, refractory hypotension and sepsis, methylene blue, greenblue discolouration of brain.

Abstract

Methylene blue is a solid; its water solution is deep blue. It has been described as “the first fully synthetic drug
used in medicine.” Methylene blue was first prepared in 1876 by German chemist Heinrich Caro. It is on the World
Health Organization’s List of Essential Medicines. It has been increasingly used in the management of refractory
distributive shock. A 16 years old boy following liver transplantation developed septicemia. During autopsy
when dissecting brain, grey matter showed colour change from grey to green-blue in a few seconds. Green-blue
discolouration of brain was an incidental finding in this case and when back referred it was found that young
male developed acute liver failure and had undergone liver transplantation. Following transplant rejection he
developed refractory hypotension, septic shock and multiple organ dysfunction syndrome. So in that critical
condition methylene blue was given which is an effective drug for refractory shock.

Author Biographies

Saritha S R

Additional Professor, Department of Forensic Medicine,Government Medical College, Thiruvananthapuram.

Greeshma C K

Junior Resident, Department of Forensic Medicine,Government Medical College, Thiruvananthapuram.

Sreedevi C S

Professor and Head, Department of Forensic Medicine,Government Medical College, Thiruvananthapuram.

Downloads

Published

2022-10-27

How to Cite

Saritha S R, Greeshma C K, & Sreedevi C S. (2022). Green-Blue Discolouration of Brain at Autopsy: A Case Report. Medico Legal Update, 22(4), 63–66. https://doi.org/10.37506/mlu.v22i4.3335