Serum Anti-Mullerian Hormone Concentration and Function of The Pituitary-Gonadal Axis in Iraqi Patients with Chronic Kidney Disease

Abstract

Infertility among patients with chronic kidney disease (CKD) has been extensively investigated. However,
reproductive function in these patients is less well‐characterized. The present study was aimed to examine
the associations among chronic kidney disease (CKD) and fertility status by evaluation levels of: Luteinizing
hormone (LH) and Follicle-stimulating hormone (FSH). Estrogen (E2) and Progesterone (P4) for females
and Testosterone for males along with Anti-Mullerian Hormone (AMH) in CKD patients. The study has
been registered at Nephrology and Transplant Center in Medical City of Baghdad- Iraq from April 2018
to July 2018. The study included 50 patients who are diagnosed to have CKD stage-5, their ages ranged
between 20-50 years (25 males and 25 females) and 20 matched apparently healthy as control, their ages
ranged between 20-48 years (10 males and 10 females). This study showed a highly significant (P<0.01)
increase in LH, FSH levels in CKD patients compared to the control group. Highly significant (P<0.01)
decrease in E2 level in CKD females patients compared to the control group, while there was non-significant
(P>0.05) decrease in P4 level in CKD females patients compared to the control group. In parallel, there is
significant (P<0.05) decrease in Testosterone level in CKD males patients compared to the control group. On
the other hand, the study showed non-significant (p>0.05) increase in AMH level in CKD patients compared
to the control group.