Testosterone and Progesterone Levels, Gene Expression of Androgen and Progesterone Receptors in Albino Male Rats Treated with Phenolic Flower Extract of Hibiscus Rosa - Sinensis L

Abstract

Hibiscus rosa sinensis L. is one of medicinal plant and belongs to the family Malvaceae , Hibiscus species are used in the treatment of many disease, flowers are used to stimulate hair growth , wounds healing activity, anti-parasitic effect , Antidiabetic anti-hyperlipidemic activity. and have many pharmacological properties including anti-fertility , antipyretic, antispasmodic, antifungal, anti-inflammatory and many more. This study was conducted in the department of Biology /College of Science/University of Babylon/Iraq , to evaluate the Effect of Phenolic Extract of Hibiscus rosa - sinensis L. flowers on some biomarkers and gene expression in Albino male Rats .The overall number of animals used were 32 male rats aged 2-3 months. The results showed a significant decrease (p<0.05) in the level of Testosterone and Progesterone in treated rats as compared with control groups for 30 and 60 days. Also the result revealed a significant decrease ( p< 0.05) in the expression of the androgen receptors and progesterone receptor in the testicular cells treatment group with phenolic compounds of H. rosa- sinensis flowers at a dose of 300mg / kg /day of body weight for 60 days compared to control groups.