Variation of Alkalinephosphatase and Transaminases Levels in Different Trimesters of Pregnancy Iraqi Women

Abstract

The level of enzymes Alkaline phosphatase (ALP) and transaminase (AST &ALT) were measured in 99 Iraqi pregnant women from different areas in Baghdad city and compared with a control group comprising non-pregnant women (29women). Those pregnant women were classified into three groups according to the semester of pregnancy. (Group I to III ). New inclusion and exclusion criteria were applied in this study to increase the specificity. The result revealed a significant increase in the corresponding enzymes (p<0.001) for each simester of pregnancy when compared with the control group(non pregnant women). There were no significant changes in enzymes activity between group1 (first trimester) and group II(second trimester) . The significant changes in ALP were observed between group1(first trimester) and group III (third trimester) p<0.001.The same trend was observed between group II (second trimester) and group III (third trimester). The result also revealed insignificant changes in AST/ALT ratio among all the groups including control group (p>0.05).
Conclusion: This study indicate the importance of the establishment of new reference values for the above mentioned enzyme during pregnancy and unsuitability of ALP in liver function test during pregnancy.