Study the Association between the Thyroid Autoimmunity Markers and Polycystic Ovary Syndrome in Euthyroid Women

Abstract

Polycystic ovary syndrome during childbearing age is consider as one of the commonest endocrine disease in reproductive age females, with a prevalence of 4% to 15%. The clinical expression of PCOS is variable, but mostly includes anovulation or oligo-ovulation, clinical or biochemical hyperandrogenism and ovarian polycystic picture in U\S. Objective: To determine the levels and prevalence of thyroid antibodies in euthyroid women has PCOS.
Patients and method: A case control study carried in the Infertility clinic of the Babylon Teaching Hospital for maternity and children in Al-Hila city, Babylon governorate, /Iraq in the period from October 1, 2018 to the end of Nov. 2019. Results: the current study found a highly statistically significant association between the studied group among the BMI (P<0.001), while no significant association between the studied groups regarding the age (P>0.05). Eighty percent of the patients (PCOS) group, and 20% in control group presented with family history with thyroid disease. Anti-TG were negative in (85.72%) of the PCOS group patients, 8.57% of the patients with borderline positive and only (5.71%) were positive (>110 IU/ml). TSH level in PCOS group (2.3 ± 0.5) were increase with significant association than that in control group (2.1 ± 0.8), highly significant increase were found in Anti-TPO, Anti-TG, free testosterone and LH in PCOS group than that in control group (P<0.001).
Conclusion: There is increased risk of thyroid disease with increase in thyroid Autoimmunity Markers in PCOS patients.