Orofacial Granulomatosis: A Review

Abstract

Orofacial Granulomatosis (OFG) is an uncommon clinicopathological entity characterized clinically by the
presence of persistent enlargement of the soft tissues of the oral and maxillofacial region and histologically
by non-caseating and non-necrotizing granulomatous inflammation. The term ‘orofacial granulomatosis’ has
been introduced to denote the group of various disorders, including Melkersson-Rosenthal syndrome and
granulomatous cheilitis and has been noted to be associated with Crohn’s disease, Sarcoidosis and infectious
diseases such as Tuberculosis. Although, various etiological agents such as dental materials, food additives
and microbial agents have been recommended in the disease process. Treatment of orofacial granulomatosis
is by corticosteroids but it’s not so efficient. It is more important to identify the pathogen first to specify the
appropriate treatment line.