Unexpected Findings: Cutaneous Metastasis in Squamous Cell Carcinoma of the Cervix – A Rare Case Report

Authors

  • Sumedha Gupta VMMC and Safdarjung Hospital New Delhi
  • Varsha Motwani VMMC & Safdarjung Hospital
  • Dheer Singh Kalwaniya VMMC & Safdarjung Hospital

DOI:

https://doi.org/10.37506/rm2tmz70

Keywords:

Cutaneous metastasis, External beam radiotherapy, Chemotherapy, Cervical carcinoma

Abstract

Skin metastasis from squamous cell carcinoma of the uterine cervix is a rare occurrence with reported incidences ranging from 0.1% to 2%. This often indicates advanced-stage disease and poor prognosis. We present the case of a 50-year-old multiparous woman diagnosed with cervical squamous cell carcinoma FIGO stage 2A1 following a six-month history of abnormal uterine bleeding. Despite initial treatment with radical hysterectomy, the patient was noncompliant with postoperative radiotherapy and experienced disease recurrence manifesting as vaginal and cutaneous lesions. Subsequent chemotherapy failed to halt disease progression, leading to palliative care. The timing of skin metastasis onset following primary treatment is a crucial prognostic factor, with earlier appearances indicating poorer outcomes. Skin metastases are often preterminal, necessitating palliative care.

Author Biographies

  • Sumedha Gupta, VMMC and Safdarjung Hospital New Delhi

    Department of Obstetrics and Gynaecology

  • Varsha Motwani, VMMC & Safdarjung Hospital

    Department of Obstetrics and Gynaecology

  • Dheer Singh Kalwaniya, VMMC & Safdarjung Hospital

    Department of Surgery 

References

Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis [published correction appears in Lancet Glob Health. 2022 Jan;10(1):e41]. Lancet Glob Health. 2020;8(2):e191-e203.

Zheng RS, Sun KX, Zhang SW, et al. ChinJOncol.2019;41(1):19-28.

Zhao X, Chen R, Zhou Q. Skin metastasis in squamous cell cancer of cervix: A case report. Prec Radiat Oncol. 2023; 7: 142–146.

Gupta PK, Lal P, Tiwari A. A case report of carcinoma of uterine cervix throwing heterochronous metastasis to the skin, spleen, and pancreas: the role of multimodality treatment approach. J Egypt Natl Canc Inst. 2019;31(1):8.

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Published

2024-10-28